Li-Ching Lee Selected Research

polyglutamine

1/2016	A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells.
12/2014	Deactivation of TBP contributes to SCA17 pathogenesis.
10/2014	The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.
6/2014	Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3.
6/2014	Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
1/2014	Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.
1/2013	Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3.
1/2012	Role of the CCAAT-binding protein NFY in SCA17 pathogenesis.

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Li-Ching Lee Research Topics

Disease

8	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2014 - 03/2010
7	Autism Spectrum Disorder 01/2022 - 06/2013
7	Autistic Disorder (Autism) 01/2019 - 11/2006
4	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2022 - 12/2017
3	Neurodevelopmental Disorders 01/2021 - 03/2007
3	Huntington Disease (Huntington's Disease) 12/2014 - 01/2013
3	Parkinson Disease (Parkinson's Disease) 01/2014 - 03/2010
2	Neuroblastoma 01/2019 - 01/2016
2	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 06/2014 - 01/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2014 - 01/2013
2	Spinocerebellar Ataxia 17 01/2012 - 02/2009
1	Allergic Rhinitis 01/2022
1	Asthma (Bronchial Asthma) 01/2022
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Wounds and Injuries (Trauma) 10/2019
1	Developmental Disabilities (Developmental Disability) 01/2019
1	Cerebellar Ataxia (Dysmetria) 12/2014
1	Retinal Degeneration 12/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2014
1	Atrophy 06/2014
1	Starvation 01/2014
1	Neuroinflammatory Diseases 01/2013
1	Nervous System Diseases (Neurological Disorders) 01/2013
1	ST Elevation Myocardial Infarction 12/2012
1	Mitral Valve Insufficiency (Mitral Regurgitation) 12/2012
1	Alzheimer Disease (Alzheimer's Disease) 03/2010
1	Parkinsonian Disorders (Parkinsonism) 03/2010
1	Obstructive Sleep Apnea 06/2009
1	Myocardial Infarction 06/2009
1	Schizophrenia (Dementia Praecox) 09/2004

Drug/Important Bio-Agent (IBA)

8	polyglutamineIBA 01/2016 - 01/2012
6	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2007
6	TATA-Box Binding Protein (TATA-Binding Protein)IBA 12/2014 - 02/2009
5	tributyl phosphate (TBP)IBA 12/2014 - 02/2009
3	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2021 - 06/2013
2	sulforaphaneIBA 06/2021 - 01/2021
2	Opioid Analgesics (Opioids)IBA 01/2019 - 01/2019
2	HDL LipoproteinsIBA 01/2018 - 12/2017
2	Peptide Initiation Factors (Initiation Factor)IBA 01/2014 - 03/2010
1	diazonaphthalenedisulfonic acid (NDS)IBA 01/2022
1	isothiocyanic acidIBA 01/2021
1	Local AnestheticsIBA 10/2019
1	Analgesics (Analgesic Drugs)IBA 10/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 07/2018
1	Acetaminophen (Paracetamol)FDA LinkGeneric 07/2018
1	Triglycerides (Triacylglycerol)IBA 12/2017
1	CholesterolIBA 12/2017
1	TriazolesIBA 01/2016
1	di- tert- butylperoxy- 3,3,5- trimethylcyclohexane peroxide (BBTC)IBA 12/2014
1	indoleIBA 10/2014
1	Mutant Proteins (Protein, Mutant)IBA 06/2014
1	HMGB1 Protein (HMG1)IBA 01/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2014
1	Serotonin (5 Hydroxytryptamine)IBA 06/2013
1	Neurotransmitter Agents (Neurotransmitter)IBA 06/2013
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2013
1	Minocycline (Cyclops)FDA LinkGeneric 01/2013
1	peoniflorinIBA 01/2013
1	AntibodiesIBA 03/2007
1	AutoantibodiesIBA 03/2007
1	AntigensIBA 03/2007
1	HLA Antigens (Human Leukocyte Antigens)IBA 11/2006
1	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 11/2006
1	Dopamine (Intropin)FDA LinkGeneric 09/2004

Therapy/Procedure

2	Therapeutics 10/2015 - 12/2012
1	Thrombolytic Therapy 12/2012
1	Deep Brain Stimulation 01/2012
1	Percutaneous Coronary Intervention 06/2009